ANALOGUES CYCLIQUES DE CALLIDINE ET LEUR PROCEDE DE PREPARATION

Novel cyclic analogues of callidine have the following general formula: wherein Pro is moiety of L-proline, Gly-that of glycine, Phe-phenylalanine, Arg-L-argenine; R is a residue of alpha - or omega -aminoacid or peptide; R1 is a residue of alpha - or omega - amino-acid; R2 is L-serine or glycine, t...

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Bibliographische Detailangaben
Hauptverfasser:	F.K. MUTULIS, O.E. LANDO, G.I. CHIPENS, N.V. MYSHLYAKOVA
Format:	Patent
Sprache:	fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel cyclic analogues of callidine have the following general formula: wherein Pro is moiety of L-proline, Gly-that of glycine, Phe-phenylalanine, Arg-L-argenine; R is a residue of alpha - or omega -aminoacid or peptide; R1 is a residue of alpha - or omega - amino-acid; R2 is L-serine or glycine, the carbonyl group of arginine being connected either with R or with R1 by means of a covalent peptide bond using the omega -amino group of the aminoacid located in the 1 or 2 position of the calladine sequence. The novel compounds according to the present invention possess a prolonged hypotensive effect of selective character.