NOUVEAUX DERIVES DE L'HYDROXYMETHYL-2 OXADIAZOLE-1

NOUVEAUX DERIVES DE L'HYDROXYMETHYL-2 OXADIAZOLE-1

Compounds of the formula WHEREIN R1 is hydrogen, aminocarbonyl or aminocarbonyl N-substituted by alkyl having up to 4 carbon atoms, R2 is halogen, alkoxy having up to 4 carbon atoms, alkyl having up to 4 carbon atoms, or trifluoromethyl N IS 0, 1, 2 OR 3 ARE PREPARED BY REACTING ETHYL HYDROXYACETIMI...

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Bibliographische Detailangaben
Hauptverfasser: G. RAYNAUD, G. HUGUET, C. FAURAN, J. THOMAS, C. DOUZON
Format: Patent
Sprache:fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds of the formula WHEREIN R1 is hydrogen, aminocarbonyl or aminocarbonyl N-substituted by alkyl having up to 4 carbon atoms, R2 is halogen, alkoxy having up to 4 carbon atoms, alkyl having up to 4 carbon atoms, or trifluoromethyl N IS 0, 1, 2 OR 3 ARE PREPARED BY REACTING ETHYL HYDROXYACETIMIDATE HYDROCHLORIDE WITH PHENYLHYDRAZIDE OR (R2)n-substituted phenylhydrazide. When R1 is other than hydrogen, that reaction product is reacting with an alkyl isocyanate, or reacted with phenylchloroformate followed by reaction with ammonia. The compounds possess analgesic, antiinflammatory, anticonvulsivant, tranquilizing, myorelaxant, antidepressive, vasodilatatory, diuretic, anti-ulcerous, antiarythmic, antiserotoninic, spasmolytic, hypotensive, antibronchocontrictive, anticholinergic and antiemetic properties.