Para-alkanoyl phenyl alkanoic acids prepn - useful as hypolipaemic agents

Para-alkanoyl phenyl alkanoic acids prepn - useful as hypolipaemic agents

Cpds. (I), (II) and (III): (I) Z = COOH; (II) Z =CN; (III) Z = Cl or Br (where R1 is H, Me or Et, R2 is H, F, Cl or 1-4C alkoxy; R3 and R4 are Me or Et) are prepd. by halogenating a p-acyl toluene to give (III), reacting this with a metal cyanide to give (II) and hydrolysing this to give phenyl alka...

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Bibliographische Detailangaben
Hauptverfasser: J. NADELSON, W.J. HOULIHAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Cpds. (I), (II) and (III): (I) Z = COOH; (II) Z =CN; (III) Z = Cl or Br (where R1 is H, Me or Et, R2 is H, F, Cl or 1-4C alkoxy; R3 and R4 are Me or Et) are prepd. by halogenating a p-acyl toluene to give (III), reacting this with a metal cyanide to give (II) and hydrolysing this to give phenyl alkanoic acids of formula (I).