Antiinflammatory pyridazines

Antiinflammatory pyridazines New cpds. (where R = furyl, thienyl pyridyl or a gp. -C6H3R1R2; R1 and R2 = H, F, Cl, 1-4C alkyl or alkoxy or CF3, cr R1 + R2 form methylenedioxy, R1 and R2 not both being CF3 on adjacent C-atoms; X = CO and Y and Z form a second bond, or X = CH2 and Y = Z = H n = 2,3 or...

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1. Verfasser: W.J. HOULIHAN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Antiinflammatory pyridazines New cpds. (where R = furyl, thienyl pyridyl or a gp. -C6H3R1R2; R1 and R2 = H, F, Cl, 1-4C alkyl or alkoxy or CF3, cr R1 + R2 form methylenedioxy, R1 and R2 not both being CF3 on adjacent C-atoms; X = CO and Y and Z form a second bond, or X = CH2 and Y = Z = H n = 2,3 or 4, R is not = phenyl, p-chlorophenyl or p-alkoxyphenyl when n = 3) and their acid addition salts when X = CH2, are prepd. by cyclisation of RCOCH2CH2COOH and H2NNH(CH2)nOH to the cpds. where X = CO, which may then be reduced.