Method for preparing camptothecin and its derivatives

The invention concerns a novel method for preparing camptothecin and its derivatives by convergent synthesis from a 3-aminomethyl quinoline derivative and 5-hydroxy 5-ethyl 6-oxo 5,6-dihydro pyran carboxylic acid and the resulting intermediates.

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Hauptverfasser: STEFANIE LEUE, YVES GENISSON, PATRICK LEON, ANDREW-ELLIOT GREENE, STEPHANIE GARCON
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Sprache:eng
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creator STEFANIE LEUE
YVES GENISSON
PATRICK LEON
ANDREW-ELLIOT GREENE
STEPHANIE GARCON
description The invention concerns a novel method for preparing camptothecin and its derivatives by convergent synthesis from a 3-aminomethyl quinoline derivative and 5-hydroxy 5-ethyl 6-oxo 5,6-dihydro pyran carboxylic acid and the resulting intermediates.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Method for preparing camptothecin and its derivatives
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