Detection of peptides

Detection of peptides

A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of cap...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MIKHAIL SOLOVIEV, ALBERT EDWARD PLATT, JOHNATHAN ALEXANDER TERRETT, ELAINE SCRIVENER, RICHARD BARRY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMBINATORIAL CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEASURING
METALLURGY
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of capture agents immobilized on a solid support, the capture agents comprising those that recognize a target protein fragment; whereby the binding of the target peptide fragments with the capture agents is indicative of the presence of the protein(s) in the sample. A device comprising such an array, and its production, are also described.