SOMATOTROPINS WITH ALTERATIONS IN THE ALPHA-HELIX 3 REGION, ALPHA-HELIX 2 REGION COMBINATIONS THEREOF, AND IN COMBINATION WITH OTHER MUTATIONS

The present invention relates to somatotropin analogues with amino acid changes in the alpha -helix 3 regions of said somatotropins, changes in the alpha -helix 2 regions, combinations thereof plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting anal...

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Bibliographische Detailangaben
1. Verfasser:	DEBORAH TARDY CHALEFF
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to somatotropin analogues with amino acid changes in the alpha -helix 3 regions of said somatotropins, changes in the alpha -helix 2 regions, combinations thereof plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptides also are provided.