Oligo-thiophenes useful as antimetastatic agents, a preparation thereof and pharmaceutical compositions containing them

Oligo-thiophenes of formula (I) are disclosed wherein: A is a -CH2-CO-, -CH2CH2-CO- or -CH=CH-CO- group; B is a 2-thienyl or a phenyl group, which is substituted by an R group, or it is a natural or synthetic amino acid, linked to the A group via its N-terminus; or A-B is a -CH2CH2-NH-A.A.- group, wherein the A.A.-group is a natural or synthetic amino acid residue, linked to the CH2CH2-NH-group via its carboxy-terminus; R is hydrogen or a chlorine, bromine, iodine, fluorine, (C1-C4)alkyle, (C1-C4)alkylene- COOR', (C1-C4)alkylene-NH2, (C1-C4)alkylene-NR'2 or (C1-C4)alkylene-NHCOR' group; R' is hydrogen or a (C1-C4)alkyl group, isomers thereof, and salts thereof with pharmaceutically acceptable acids and bases. It is also claimed the use of the compounds of formula (I) as inhibitors of the uPA binding to the specific uPAR receptor, in particular their application as antitumor and antimetastatic agents.