New metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof

Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumor...

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Hauptverfasser: BARBARA GORINI, MARIO PAGLIALUNGA PARADISI, GIOVANNISTAZIO, MAURIZIO CIRILLI, SILVANA D'ALESSIO, CINZIA PIAZZA, VINCENZO POLITI, ENRICO GAVUZZO, ANTONIO SELLA, GIORGIO POCHETTI, FERNANDO MAZZA, CARLO GALLINA, CESARE GIORDANO, GABRIELLA PANINI
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creator BARBARA GORINI
MARIO PAGLIALUNGA PARADISI
GIOVANNISTAZIO
MAURIZIO CIRILLI
SILVANA D'ALESSIO
CINZIA PIAZZA
VINCENZO POLITI
ENRICO GAVUZZO
ANTONIO SELLA
GIORGIO POCHETTI
FERNANDO MAZZA
CARLO GALLINA
CESARE GIORDANO
GABRIELLA PANINI
description Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases.Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
title New metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof
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