New metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof

Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumor...

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Hauptverfasser: BARBARA GORINI, MARIO PAGLIALUNGA PARADISI, GIOVANNISTAZIO, MAURIZIO CIRILLI, SILVANA D'ALESSIO, CINZIA PIAZZA, VINCENZO POLITI, ENRICO GAVUZZO, ANTONIO SELLA, GIORGIO POCHETTI, FERNANDO MAZZA, CARLO GALLINA, CESARE GIORDANO, GABRIELLA PANINI
Format: Patent
Sprache:eng
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Zusammenfassung:Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases.Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.