Drug discharge pump inhibitors

A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a...

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Bibliographische Detailangaben
Hauptverfasser:	JASON ZHIJIA ZHANG, WILLIAM JOHN WATKINS, TOSHIHARU OHTA, THOMAS ERIC RENAU, YOHHEI ISHIDA, MASAMI OHTSUKA, HARUKO KAWATO, KIYOSHI NAKAYAMA, ROGER LEGER, VING JACK LEE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a physiologically acceptable salt thereof, or a hydrate thereof: wherein R 1 and R 2 independently represent hydrogen atom, a halogen atom, carboxyl group and the like; J 1 represents a 5- or 6-membered heteroaromatic ring; W 1 represents -CH=CH-, -C¡C-, -CH 2 CH 2 - and the like; A 1 represents phenylene group, pyridinediyl group, furandiyl group and the like; G 1 represents oxygen atom, carbonyl group, ethynyl group and the like; p represents an integer of from 0 to 3; G 2 represents phenylene group, furandiyl group, tetrahydrofurandiyl group and the like; G 3 represents -CH 2 - or single bond; m and n represent an integer of 0 or 1; and Q 1 represents an acidic group.