Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring

Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring

This invention relates to the discovery of novel and useful alpha -amino acid analogs, and the pharmaceutically acceptable salts and prodrugs thereof, containing a disubstituted pyrrolidine ring conjugated to an alpha -amino acid, useful as inhibitors of thrombin.

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Bibliographische Detailangaben
Hauptverfasser: GREGORY JAMES PACOFSKY, JAMES RUSSELL PRUITT, PATRICIA CAROL WEBER
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention relates to the discovery of novel and useful alpha -amino acid analogs, and the pharmaceutically acceptable salts and prodrugs thereof, containing a disubstituted pyrrolidine ring conjugated to an alpha -amino acid, useful as inhibitors of thrombin.