Process for preparing 6-O-alkenyl-substituted erythromycin derivatives
In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. I...
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| creator | ANTHONY R. HAIGHT DAVID R. HILL JAMES J. NAPIER TIM GRIEME PRASAD S. RAJE JIEN-HEH J. TIEN MARGARET CHI-PING HSU STEVEN J. WITTENBERGER MAHENDRA N. DESHPANDE MARVIN R. LEANNA MAUREEN A. MCLAUGHLIN DAVID RILEY MATTHEW J. PETERSON ARTHUR J. COOPER DANIEL J. PLATA YI-YIN KU MICHAEL RASMUSSEN ERIC J. STONER HOWARD E. MORTON RUSSELL D. CINK ELAINE C. LEE STEVEN A. KING |
| description | In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction. |
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KING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for preparing 6-O-alkenyl-substituted erythromycin derivatives</title><date>2005-01-13</date><risdate>2005</risdate><abstract>In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | Process for preparing 6-O-alkenyl-substituted erythromycin derivatives |
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