Process for preparing 6-O-alkenyl-substituted erythromycin derivatives

In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. I...

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Bibliographische Detailangaben
Hauptverfasser:	ANTHONY R. HAIGHT, DAVID R. HILL, JAMES J. NAPIER, TIM GRIEME, PRASAD S. RAJE, JIEN-HEH J. TIEN, MARGARET CHI-PING HSU, STEVEN J. WITTENBERGER, MAHENDRA N. DESHPANDE, MARVIN R. LEANNA, MAUREEN A. MCLAUGHLIN, DAVID RILEY, MATTHEW J. PETERSON, ARTHUR J. COOPER, DANIEL J. PLATA, YI-YIN KU, MICHAEL RASMUSSEN, ERIC J. STONER, HOWARD E. MORTON, RUSSELL D. CINK, ELAINE C. LEE, STEVEN A. KING
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.