Process for the separation of enantiomers

Process for the separation of enantiomers

PCT No. PCT/US94/09687 Sec. 371 Date Feb. 20, 1996 Sec. 102(e) Date Feb. 20, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/05879 PCT Pub. Date Mar. 2, 1995A process for separating enantiomeric mixtures by liquid chromatography using a stationary phase that includes cellulose or amylose derivative a...

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Bibliographische Detailangaben
Hauptverfasser: LAWRENCE W NICHOLSON, CURTIS D PFEIFFER, CHRISTIAN T. GORALSKI
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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Zusammenfassung:PCT No. PCT/US94/09687 Sec. 371 Date Feb. 20, 1996 Sec. 102(e) Date Feb. 20, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/05879 PCT Pub. Date Mar. 2, 1995A process for separating enantiomeric mixtures by liquid chromatography using a stationary phase that includes cellulose or amylose derivative and a mobile phase that includes methanol and pentane, the concentration of methanol in the mobile phase being greater than one tenth percent by volume and less than the saturation concentration of methanol in the mobile phase, the concentration of pentane being at least that necessary to resolve the enantiomeric mixture into its enantiomers with a resolution at least one and one half times greater than the pentane of the mobile phase is replaced with hexane.