Sulphonamide derivatives

Sulphonamide derivatives

The present invention provides compounds of the formula: wherein R14 represents a phenyl group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)zX3R15 in which z is 0 or an integer of...

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Bibliographische Detailangaben
Hauptverfasser: KEN MATSUMOTO, STEPHEN R. BAKER, MACKLIN B. ARNOLD, RICHARD L. SIMON, EDWARD C. R. SMITH, ANA M. ESCRIBANO, THOMAS J BLEISCH, PAUL L. ORNSTEIN, DAVID BLEAKMAN, DENNIS M. ZIMMERMAN, BUDDY E. CANTRELL, HAMIDEH ZARRINMAYEH, JOSEPH P. TIZZANO, TRACEY E. MCKENNON
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides compounds of the formula: wherein R14 represents a phenyl group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)zX3R15 in which z is 0 or an integer of from 1 to 4, X3 represents O, S, NR16, CO, COO, OCO, CONR17, NR18CO, OCONR19, R15 represents hydrogen, (1-10C) alkyl, (3-10C)alkenyl, (3-10C)alkynyl or (3-8C)-cycloalkyl and R16, R17, R18 and R19 each independently represents hydrogen or (1-10C)alkyl, or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising these compounds.