Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N;d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independe...

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Bibliographische Detailangaben
Hauptverfasser:	MATTHEW G. STANTON, KENNETH J. STAUFFER, PHILIP E. SANDERSON, CHRISTOPHER BURGEY, TERRY A. LYLE, JAMES C. BARROW, BRUCE D. DORSEY, PHILIPPE G. NANTERMET, PETER D. WILLIAMS, CRAIG COBURN, ADEL M. NAYLOR-OLSEN, MATTHEW M. MORRISSETTE, DONNETTE STAAS, HAROLD G. SELNICK, RICHARD ISAACS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N;d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independently hydrogen, C1-4 alkyl, or halogen; Y1 and Y2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y3 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, -CN, NH2, OH or C1-4 alkoxy;A isand W, W1, R1, R3, R4, R5, X and Z are defined in the specification.