Substituted isoquinolines as ultra short acting neuromuscular blockers

Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed,wherein q and t are independently from 0 to 4; and X1 and X2 are independently halogen; ha and hb are independently from 0 to 2; Z1 and Z2 are independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl with the proviso that Z1 and Z are not both hydrogen; Y1, Y2, Y3 and Y4 are independently hydrogen, halogen or C1-C3 alkoxy; m and p are independently 1 to 6; n and r are independently 0 to 4; with the proviso that if ha and hb are both 0, then r is 0 and n is 0 to 2; R1 and R14 are independently hydrogen, halogen, C1-C3 alkoxy, or R2 and R3 together with the carbon atoms to which they are bonded, R5 and R6 together with the carbon atoms to which they are bonded, may independently form a methylenedioxy or ethylenedioxy moiety contained in a five- or six-membered ring; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.