Method of producing a metal sol reagent containing colloidal metal particles of a preselected size

A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size,...

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Hauptverfasser: DENNIS M MOCHNAL, HENRY A. GRAHAM JR, SHIN CHEN, SHARON R. LAWLER, HOUSTON G. BROOKS JR, UTPAL R. CHAURABORTY, LLOYD L. HOLLENBECK JR, CHI-DEU CHANG, JEMO KANG, JENNIFER NASSER, ERNEST G. SCHUTT, ALBERT VENTURINI
Format: Patent
Sprache:eng
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Zusammenfassung:A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.