SYNTHESIS OF 4-AMINO-1,2-HYDROCARBYL PYRAZOLIDINES VIA 4- NITRO ANALOGS

SYNTHESIS OF 4-AMINO-1,2-HYDROCARBYL PYRAZOLIDINES VIA 4- NITRO ANALOGS

4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceut...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: H.R. MUNSON, Y.S. LO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: wherein R1 and R2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.