Method for the production of non-immunogenic proteins

The invention relates to a specific method of rendering therapeutic non-human proteins non or les immunogenic compared to a given human individual by identifying and modifying peptides within T-cell epitopes of said proteins, which bind to MHC class II molecules or show the ability to stimulate T-ce...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ANITA ANNE HAMILTON, FIONA SUZANNE ADAIR, FRANCIS JOSEPH CARR, GRAHAM CARTER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The invention relates to a specific method of rendering therapeutic non-human proteins non or les immunogenic compared to a given human individual by identifying and modifying peptides within T-cell epitopes of said proteins, which bind to MHC class II molecules or show the ability to stimulate T-cells via presentation on MHC class II.