Pyrrolidine derivatives having phospholipase A2 inhibitory activity

Pyrrolidine derivatives having phospholipase A2 inhibitory activity

A compound represented by the formula (I): wherein, for example, R is optionally substituted aralkyl, Z is nitrogen atom which optionally substituted with alkyl, X is -CH2NHCO-, X is phenylene, X is a bond, Y is optionally substituted aryl, B is oxygen atom, its pharmaceutically acceptable salt, or...

Ausführliche Beschreibung

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Hauptverfasser: MITSUAKI OHTANI, FUMIHIKO WATANABE, KAORU SENO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound represented by the formula (I): wherein, for example, R is optionally substituted aralkyl, Z is nitrogen atom which optionally substituted with alkyl, X is -CH2NHCO-, X is phenylene, X is a bond, Y is optionally substituted aryl, B is oxygen atom, its pharmaceutically acceptable salt, or hydrate thereof and a pharmaceutical composition which contains them as an active ingredient.