Imidazole derivatives as therapeutic agents

Compounds of the formula Iand pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, -NR13R14, -N(R15)SO2R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, -S(...

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Hauptverfasser: DAVID JOHN CALDERWOOD, ADRIAN JOHN FISHER, JAMES EDWARD JEFFERY, PAUL RAFFERTY, COLIN GERHART PRYCE JONES
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds of the formula Iand pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, -NR13R14, -N(R15)SO2R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, -S(O)nR7, alkoxycarbonylalkyl, carboxyalkyl, -CONR13R12 carbamoylvinyl, -OSO2R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl or -NR60R61; or R1 represents a group of formula -(O)z-L3G wherein z equals 0 or 1, L3 represents a C1-4 alkylene chain, G represents a group of formula a), b), c), or d): a) -NR22R23; b) -S(O)mR26; c) CONR27R28; d) -OR29; R2 and R3 independently represent hydrogen, halo, alkyl, alkoxy, -NR13R14, halogenated alkoxy, halogenated alkyl, hydroxy, -S(O)nR7 or -NR60R61; L1 represents e) a bond, or f) alkylene, cycloalkylene or cycloalkylidene; T represents a bond or O, S, SO, SO2, a carbonyl group, or 1,3-dioxolan-2-ylidene; L2 represents alkylene, cycloalkylene, or cycloalkylidene; R6 represents hydrogen or alkyl (optionally substituted by alkoxycarbonyl or hydroxy); Q represents a C1-9 alkylene chain (optionally substituted by alkyl or hydroxy); and Y represents an optionally substituted imidazole ring; which are antiinflammatory, antiallergic and immunodulant agents. Compositions containing these compounds and processes to make them are also disclosed.