Purification of hemoglobin

The present invention relates to a method for the production of a substantially protoporphyrin IX free hemoglobin solution comprising: rapidly heating a crude protoporphyrin IX-containing hemoglobin solution for a relatively short time and at a relatively high temperature to reduce protoporphyrin IX...

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Bibliographische Detailangaben
Hauptverfasser: DANIEL E HOUK, LEE R WILLIAMS, DAVID C HOGENSON, DAVID J MITCHELL, MARK L CHIVERS, ERIN E MILNE, DAVID W TRAYLOR, J. JEFFREY PLOMER, JAMES R RYLAND, MAURA-ANN H MATTHEWS, STEVEN K RAUSCH, ULRICH P ERNST
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a method for the production of a substantially protoporphyrin IX free hemoglobin solution comprising: rapidly heating a crude protoporphyrin IX-containing hemoglobin solution for a relatively short time and at a relatively high temperature to reduce protoporphyrin IX-containing hemoglobin to insignificant levels in said protoporphyrin IX-containing hemoglobin solution.