Quadrivalent combination vaccine including diphtheria toxoid, tetanus toxoid, whole cell pertussis and hepatitis b surface antigen, and preparation method thereof

Quadrivalent combination vaccine including diphtheria toxoid, tetanus toxoid, whole cell pertussis and hepatitis b surface antigen, and preparation method thereof

A quadrivalent (DTwPH) combination vaccine comprising diphtheria toxoid, tetanus toxoid, whole cell pertussis, and HBsAg, and a method for preparing the same are provided. In the preparation of the DTwPH combination vaccine, diphtheria toxoid and tetanus toxoid are adsorbed onto aluminum phosphate (...

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Bibliographische Detailangaben
Hauptverfasser: CHEON-SOON BAE, JONG-SOO KIM, DAL-HO UM, GWAN-YEUL LIM, KYUNG-NAM PARK, HONG-JOO KIM
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A quadrivalent (DTwPH) combination vaccine comprising diphtheria toxoid, tetanus toxoid, whole cell pertussis, and HBsAg, and a method for preparing the same are provided. In the preparation of the DTwPH combination vaccine, diphtheria toxoid and tetanus toxoid are adsorbed onto aluminum phosphate (AlPO4) gels, and HBsAg is adsorbed onto aluminum hydroxide (Al(OH)3) gel. The DTwPH combination vaccine is adjusted to have a final pH of 6.5-7.5, and the concentrations of constituents also adjusted with the concentration of aluminum hydroxide gel in the range of 15-35 mu gAl/mL.