Ganglioside analogs

PCT No. PCT/DK92/00333 Sec. 371 Date Sep. 12, 1994 Sec. 102(e) Date Sep. 12, 1994 PCT Filed Nov. 11, 1992 PCT Pub. No. WO93/10134 PCT Pub. Date May 27, 1993Ganglioside lactam analogue derivatives of general formula (I) in which A is a sialic acid residue of formula (II) which is bound via the dashed...

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Hauptverfasser:	HANS GORAN MAGNUSSON, KUMAR RAY ASIM
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/DK92/00333 Sec. 371 Date Sep. 12, 1994 Sec. 102(e) Date Sep. 12, 1994 PCT Filed Nov. 11, 1992 PCT Pub. No. WO93/10134 PCT Pub. Date May 27, 1993Ganglioside lactam analogue derivatives of general formula (I) in which A is a sialic acid residue of formula (II) which is bound via the dashed line in the 2-position; and in which Z1 is -OH or a group -NHX1, and Y30 is -CH3 or -CH2OH; X1 and Y1 together form a bond and Y2 is -OH or a group OR20, or X1 and Y2 together form a bond and Y1 is -OH or -NHAc; Y3 is -OH or a group -OR20; R1 is H or a sialic acid residue of formula (III) which is bound via the dashed line in the 2-position; and in which Z2 is -OH or a group -NHX2, and Y30 is as defined above; X2 and Y10 together form a bond and Y20 is -OH, or X2 and Y20 together form a bond and Y10 is -OH; with the provisos that when R1 is H, then Z1 is -NHX1, and that when R1 is a sialic acid residue of formula (III), then at least one of Z1 and Z2 is different from -OH; R10 is H, a carrier CA, or a group -(Sugar)n. The compounds are hydrolytically stable lactam analogs which spatially closely resemble the naturally occurring ganglioside lactones and are antigenic and able to induce the production of antibodies that cross-react with the corresponding ganglioside lactone.