Method and device for heterogeneous phase synthesis of macromolecules such as peptides, polynucleotides or oligosaccharides

PCT No. PCT/FR92/00197 Sec. 371 Date Sep. 7, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Mar. 4, 1992 PCT Pub. No. WO92/15867 PCT Pub. Date Sep. 17, 1992.Method and device for the synthesis of macromolecules, including peptides, polynucleotides or oligosaccharides. The method and device involves a...

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Hauptverfasser:	ROGER POISSON, GERARD LAPLUYE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SUGARS TESTING THEIR RELEVANT APPARATUS TRANSPORTING
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Zusammenfassung:	PCT No. PCT/FR92/00197 Sec. 371 Date Sep. 7, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Mar. 4, 1992 PCT Pub. No. WO92/15867 PCT Pub. Date Sep. 17, 1992.Method and device for the synthesis of macromolecules, including peptides, polynucleotides or oligosaccharides. The method and device involves a reactor which contains a solid support on which a component of the product to be synthesized is fixed. The reactor comprises filters at its ends and is mounted movably for rectilinear reciprocating movement in a vessel which contains a reactive liquid. A temperature probe is provided to detect the temperature variations of the reactive liquid due to passage into and out of the reactor. The progress of coupling and deprotection reactions which occur in the synthesis of peptides, polynucleotides and oligosaccharides is monitored.