Chrysospermins, active peptides from apiocrea chrysosperma having a pharmacological effect, a process for their preparation and the use thereof

The invention relates to the peptide drugs chrysospermines of the formula I in which x and y denote, independently of one another, Aib or Iva, which are synthesised by the fungus Apiocrea chrysosperma during fermentation and accumulate in the culture broth, to a preparation process, to the use of th...

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Hauptverfasser:	UDO GRAFE, BRIGITTE SCHLEGEL, WOLFGANG SCHADE, JORG METZGER, WOLFGANG IHN, KLAUSJURGEN DORNBERGER, WERNER FRIEDRICH FLECK
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the peptide drugs chrysospermines of the formula I in which x and y denote, independently of one another, Aib or Iva, which are synthesised by the fungus Apiocrea chrysosperma during fermentation and accumulate in the culture broth, to a preparation process, to the use of the chrysospermines as pharmacological agents, in particular as agent against bacteria, fungi and/or nematodes and for the treatment of rejection reactions to organ transplants and of tumours, and to the microorganism Apiocrea chrysosperma DSM 7444.