Novel oxa- or azasteroid derivative

Novel oxa- or azasteroid derivative

A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH2, C=CH2 or C=CH-lower alkyl; B repr...

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Hauptverfasser: NAOYUKI KOIZUMI, SHIGEHIRO TAKEGAWA, KENYU SHIBATA, SHIGEKI IWASHITA, MAMORU MIEDA, SEIJIRO HONMA, TOMOKO KAWACHI, KOICHI MINATO, HIROO TAKAHASHI, MITSUTERU NUMAZAWA, TERUAKI MATSUI
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Sprache:eng
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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creator NAOYUKI KOIZUMI
SHIGEHIRO TAKEGAWA
KENYU SHIBATA
SHIGEKI IWASHITA
MAMORU MIEDA
SEIJIRO HONMA
TOMOKO KAWACHI
KOICHI MINATO
HIROO TAKAHASHI
MITSUTERU NUMAZAWA
TERUAKI MATSUI
description A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH2, C=CH2 or C=CH-lower alkyl; B represents O, NH or N-lower alkyl; X is nil, or represents C=O or CH2; n is 2 or 3 when X is nil, or 1 or 2 when X represents C=O or CH2; and the broken line between the 1-position and the 2-position in the steroidal skeleton means an optional presence of a double bond therebetween.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
title Novel oxa- or azasteroid derivative
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