Novel oxa- or azasteroid derivative

Novel oxa- or azasteroid derivative

A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH2, C=CH2 or C=CH-lower alkyl; B repr...

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Bibliographische Detailangaben
Hauptverfasser: NAOYUKI KOIZUMI, SHIGEHIRO TAKEGAWA, KENYU SHIBATA, SHIGEKI IWASHITA, MAMORU MIEDA, SEIJIRO HONMA, TOMOKO KAWACHI, KOICHI MINATO, HIROO TAKAHASHI, MITSUTERU NUMAZAWA, TERUAKI MATSUI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH2, C=CH2 or C=CH-lower alkyl; B represents O, NH or N-lower alkyl; X is nil, or represents C=O or CH2; n is 2 or 3 when X is nil, or 1 or 2 when X represents C=O or CH2; and the broken line between the 1-position and the 2-position in the steroidal skeleton means an optional presence of a double bond therebetween.