A new 5H-benzodiazepine derivative, pharmaceutical compositions containing same and process for preparing them

The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of formula (I) (I) and pharmaceutically acceptable acid addition salts thereof, furthermore to a process for preparing these compounds. The compounds according to the invention possess valuable an...

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Hauptverfasser: GABOR ZOLYOMI, MARTA RUSZ, FERENC ANDRASI, TAMAS HAMORI, PETER BOTKA, EVA TOMORI, JENO KOROSI, IMRE MORAVCSIK, GYULA HORVATH, KATALIN GOLDSCHMIDT
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creator GABOR ZOLYOMI
MARTA RUSZ
FERENC ANDRASI
TAMAS HAMORI
PETER BOTKA
EVA TOMORI
JENO KOROSI
IMRE MORAVCSIK
GYULA HORVATH
KATALIN GOLDSCHMIDT
description The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of formula (I) (I) and pharmaceutically acceptable acid addition salts thereof, furthermore to a process for preparing these compounds. The compounds according to the invention possess valuable anxiolytic, antiaggressive and antidepressant effects and have at the same time favorable acute toxicity values, so they can be used to advantage in therapy.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title A new 5H-benzodiazepine derivative, pharmaceutical compositions containing same and process for preparing them
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