3-deoxy-mannosamine derivatives and process for their preparation

3-Deoxy-derivatives of D-mannosamine of formula wherein R is -NH2 or a C2-C5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy...

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Bibliographische Detailangaben
Hauptverfasser:	NICOLA MONGELLI, NUCCIA ONETO, ALBERTO BARGIOTTI, CRISTINA GERONI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	3-Deoxy-derivatives of D-mannosamine of formula wherein R is -NH2 or a C2-C5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy and R2 is hydrogen then R is other than -NH2, and pharmaceutically acceptable salts thereof, are useful as angiogenesis inhibitors, in particular as inhibitors of the development of metastasis.