Optical isomers of 7-(3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl)-quinolones and naphthyridones as antibacterial agents

Optical isomers of 7-(3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl)-quinolones and naphthyridones as antibacterial agents

Optically pure isomers of 7-(3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl)quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacterial infections therewith. Also described is a...

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Bibliographische Detailangaben
Hauptverfasser: SUSAN ELIZABETH HAGEN, MARK JAMES SUTO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Optically pure isomers of 7-(3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl)quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacterial infections therewith. Also described is a method of manufacture of the quinolones and naphthyridones as well as the starting materials, the optically pure pyrrolidine moieties for attachment at the 7-position.