USE OF FOLIC ACID FOR REDUCING THE TOXICITY OF ANTITUMOR ANTIFOLATE AGENTS AND METHODS FOR TREATING TUMOURS

USE OF FOLIC ACID FOR REDUCING THE TOXICITY OF ANTITUMOR ANTIFOLATE AGENTS AND METHODS FOR TREATING TUMOURS

Administration of a folate binding protein binding agent in conjunction with use of an antitumor agent which is an inhibitor of glycinamide ribonucleotide transformylase or other antifolate reduces the toxic effects of such agent and provides an enhanced therapeutic index.

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Bibliographische Detailangaben
Hauptverfasser: GERALD BURR GRINDEY, CHUAN SHIH
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Administration of a folate binding protein binding agent in conjunction with use of an antitumor agent which is an inhibitor of glycinamide ribonucleotide transformylase or other antifolate reduces the toxic effects of such agent and provides an enhanced therapeutic index.