MACROLIDES FOR THE TREATMENT OF REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASES

Compounds of formula (I), wherein R and R together represent two vicinal hydrogen atoms, or form a second bond between the vicinal carbon atoms to which they are attached; R represents H, OH, alkoxy or protected hydroxy; R represents OH; R represents H, alkyl or alkenyl; R and R independently repres...

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Hauptverfasser:	IKUO AKUTSU, DALE MICHAEL JACKSON, TAKESHI FUKUDA, ALAN ANTHONY NORRIS, SOHEI MAKINO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	IKUO AKUTSU DALE MICHAEL JACKSON TAKESHI FUKUDA ALAN ANTHONY NORRIS SOHEI MAKINO
description	Compounds of formula (I), wherein R and R together represent two vicinal hydrogen atoms, or form a second bond between the vicinal carbon atoms to which they are attached; R represents H, OH, alkoxy or protected hydroxy; R represents OH; R represents H, alkyl or alkenyl; R and R independently represent O, (H,OH), (H,protected hydroxy) or (H,alkoxy); X and Y independently represent O, (H,OH) or (H,H); n is 1 or 2; or pharmaceutically acceptable derivatives thereof; are provided for the treatment of reversible obstructive airways disease, particularly asthma. Compositions containing such compounds are also disclosed.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	MACROLIDES FOR THE TREATMENT OF REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASES
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