PROCESS FOR PREPARING 1-((2S)-3-MERCAPTO-METHYL-1-OXOPROPYL)-L-PROLINE

PROCESS FOR PREPARING 1-((2S)-3-MERCAPTO-METHYL-1-OXOPROPYL)-L-PROLINE

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) (II) in an inert solvent, in the presence of a catalyst, at a...

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Bibliographische Detailangaben
Hauptverfasser: ILMA DINNYES, ELEMER JAKFALVI, GABOR BLASKO, ANDRAS DIETZ, GEZA SCHNEIDER, ANGES KOVACS, JUDIT KUN, GABRIELLA URMOS, IVAN BECK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) (II) in an inert solvent, in the presence of a catalyst, at a temperature of 50 DEG to 120 DEG C. under a pressure of 105 to 107 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). (III)