Bicyclic antagonists selective for the alphavbeta3 integrin

This invention provides novel bicyclic compounds of Formula (I):wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II)wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3...

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Bibliographische Detailangaben
Hauptverfasser:	KENNETH LEWIS KEES, JOHN YARDLEY, DIANE BARBARA HAUZE, ARIE ZASK, RICHARD DALE COGHLAN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention provides novel bicyclic compounds of Formula (I):wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II)wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.