Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination

The present invention relates to a process for extracting transforming growth factor beta (TGF- beta ) and insulin-like growth factor 1 (IGF-1) from a milk product, comprising the steps of: a) recovering a basic fraction from the milk product by means of cationic exchange chromatography; b) passing...

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Bibliographische Detailangaben
Hauptverfasser:	MARINUS GERARDUS CORNELIS KIVITS, LEONARD FRANCISCUS MALLEE, ANDOR WILHELM JOSEPH HENDRICKS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS HUMAN NECESSITIES METALLURGY ORGANIC CHEMISTRY PEPTIDES PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS PROTEIN COMPOSITIONS FOR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES WORKING-UP PROTEINS FOR FOODSTUFFS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for extracting transforming growth factor beta (TGF- beta ) and insulin-like growth factor 1 (IGF-1) from a milk product, comprising the steps of: a) recovering a basic fraction from the milk product by means of cationic exchange chromatography; b) passing the fraction obtained in step a) over a hydroxyapatite column; c) eluting the hydroxyapatite column with appropriate eluents in such a way as to obtain two separate fractions, these fractions being: i) a fraction comprising IGF-1 in the substantial absence of TGF- beta ; ii) a fraction comprising TGF- beta in the substantial absence of IGF-1. This process can comprise a further step d) in which a lactoperoxidase fraction can be obtained. The invention further relates to the products obtained with this process.