ANTHRAQUINONE DERIVATIVES

1416248 Anthraquinone derivatives RICHARDSON-MERRELL Inc 17 Dec 1973 [21 Dec 1972] 58267/73 Heading C2C Novel compounds of Formula I wherein n is an integer of from 2 to 6; R and R 1 are each hydrogen, lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms or alkenyl having from 3 to 6 carbon atoms in which the unsaturation is in a position other than in the 1-position of the alkenyl group, or when R and R 1 are taken together with the nitrogen atom to which they are attached represent the pyrrolidinyl, piperidino or morpholino radicals; and the pharmaceutically acceptable acid addition salts thereof are prepared by reaction of a compound of Formula II with the amine Y-(CH 2 ) n -N.R.R, wherein X is OH and Y is Cl or Br and Y is OH when X is Cl or Br. Anthraquinone - 1,5 - dicarboxylic acid is prepared by hydrolysis of 1,5-dicyanoanthraquinone obtained by reaction of cuprous cyanide and 1,5-dichloro-anthraquinone. Antiviral compositicos in conventional forms for oral, parenteral or topical administration comprise an above novel compound and an excipient.