FACTOR VII/VIIA ACTIVE SITE INHIBITORS
The invention includes a class of compounds that inhibit the specific proteolytic activity of the bimolecular complex 1[TF:VII/VIIa] that initiates the blood coagulation systems. Both reversible and irreversible inhibitors are disclosed. The invention encompasses the use of inhibitors of the active...
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Zusammenfassung: | The invention includes a class of compounds that inhibit the specific proteolytic activity of the bimolecular complex 1[TF:VII/VIIa] that initiates the blood coagulation systems. Both reversible and irreversible inhibitors are disclosed. The invention encompasses the use of inhibitors of the active site of the factor VII and VIIa component of [TF:VII/VIIa] as diagnostic reagents, as analytical reagents, and as therapeutic drugs. The invention includes the compounds based on the following general formula for both reversible and irreversible selective inhibition of [TF:VII/VIIa]. |
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