SURFCACE/INTERSPERSED P. FALCIPARUM ANTIGEN NUCLEOTIDE

DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P.falciparum...

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Bibliographische Detailangaben
Hauptverfasser: GRAHAM FRANK MITCHELL, ROBIN FREDRIC ANDERS, GRAHAM VALLANCEY BROWN, DAVID JAMES KEMP, ROSS LEON COPPEL, ALAN FREDERICK COWMAN, ALBERT EDWARD BIANCO, ROBERT BRYCE SAINT
Format: Patent
Sprache:eng
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Zusammenfassung:DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P.falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the RESA or FIRA antigens of P.falciparum. Compositions for stimulating immune responses against P.falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of the RESA or FIRA antigens of P. falciparum, together with a pharmaceutically acceptable carrier therefor.