PROCESS AND COMPOSITIONS OF THE PREPARATION OF EGLIN PROTEASE INHIBITORS

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE An eglin compound of the formula VGluPheGlySerGluLeuLysSerPhePro GluValValGlyLysThrValAspGlnAlaArgGlu TyrPheThrLeuHisTyrProGlnTyrAspVal WPheLeuProGluGlySerProValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyr AsnProGlyThrAsnValVa...

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Hauptverfasser:	HANS FRITZ, WALTER MARKI, PETER SIEBER, HANS RINK, SEFIK ALKAN, FRANCOIS MEYER, WERNER RITTEL, MANFRED LIERSCH, URSULA SEEMULLER
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE An eglin compound of the formula VGluPheGlySerGluLeuLysSerPhePro GluValValGlyLysThrValAspGlnAlaArgGlu TyrPheThrLeuHisTyrProGlnTyrAspVal WPheLeuProGluGlySerProValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyr AsnProGlyThrAsnValValAsnHisValProHis ValGly in which V is N-acetyl-Thr and W is Tyr or His, and a pharmaceutically acceptable salt thereof. 1. Claims for the Contracting State : AT A process for the preparation of Nalpha -acetyl-eglin B, Nalpha -acetyl-eglin C and a salt thereof which comprises culturing an Escherichia coli or Saccharomyces cerevisiae strain which has been transformed with a DNA vector containing a DNA sequence coded for eglin B or eglin C and suitable for expression in E. coli or S. cerevisiae, in a liquid nutrient medium containing assimilatable sources of carbon and nitrogen, releasing the product from the host cells and isolating it, and, if desired, converting a resulting salt into the free polypeptide and converting a resulting polypeptide into a salt thereof.