ANTIHYPERTENSIVE DIHYDROPYRIDINE DERIVATIVES

Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond; R1 and R2 are...

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Hauptverfasser: ROBIN D. CLARK, MOYSEY M. POVZHITKOV
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MOYSEY M. POVZHITKOV
description Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond; R1 and R2 are each independently, A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH; A2 is -(CH2)qCH(3-r)[(CH2)sOH]r; A3 is -(CH2)qCH(3-r)[(CH2)PCOOR3]r; and A4 is -(CH2)mCOOR3; where m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is -NO2, -CF3, or halo; and R5 is lower alkyl or -CH2CH2OCH3.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTIHYPERTENSIVE DIHYDROPYRIDINE DERIVATIVES
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