ANTIHYPERTENSIVE DIHYDROPYRIDINE DERIVATIVES

Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond; R1 and R2 are...

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Bibliographische Detailangaben
Hauptverfasser:	ROBIN D. CLARK, MOYSEY M. POVZHITKOV
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond; R1 and R2 are each independently, A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH; A2 is -(CH2)qCH(3-r)[(CH2)sOH]r; A3 is -(CH2)qCH(3-r)[(CH2)PCOOR3]r; and A4 is -(CH2)mCOOR3; where m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is -NO2, -CF3, or halo; and R5 is lower alkyl or -CH2CH2OCH3.