Potentiation of temozolomide in human tumour cells

The toxicity of temozolomide, an anti-tumour agent useful in the treatment of various mammalian neoplasms, can be potentiated by the prior administration of an ATase inhibiting agent, i.e., O -benzylguanine.

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Bibliographische Detailangaben
Hauptverfasser:	AZADEH ALISON FREEMAN, JOSEPH ANTHONY RAFFERTY, GEOFFREY PAUL MARGISON, JOHN COLIN BAER, EDWARD STUART NEWLANDS, AMANDA JEAN WATSON
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The toxicity of temozolomide, an anti-tumour agent useful in the treatment of various mammalian neoplasms, can be potentiated by the prior administration of an ATase inhibiting agent, i.e., O -benzylguanine.