ADENOSINE-5@-CARBOXAMIDES

ADENOSINE-5@-CARBOXAMIDES

1399670 Adenosine-51-carboxamides ABBOTT LABORATORIES 29 March 1973 [10 April 1972] 15214/73 Heading C2C Compounds I in which R 1 and R 2 are hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 haloalkenyl, C 2-6 hydroxyalkenyl, C 2-6 alkynyl, C 2-6 hal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: FRANCIS ELMER FISCHER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:1399670 Adenosine-51-carboxamides ABBOTT LABORATORIES 29 March 1973 [10 April 1972] 15214/73 Heading C2C Compounds I in which R 1 and R 2 are hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 haloalkenyl, C 2-6 hydroxyalkenyl, C 2-6 alkynyl, C 2-6 haloalkynyl, benzyl, phenyl C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy C 1-4 alkyl, substituted phenyl, 2-methylfuryl, di-(C 1-4 alkyl)amino-C 1-4 alkyl or adamantyl or NR 1 R 2 form a heterocyclic ring and their acid addition salts are prepared by reacting an ester of adenosine-51-carboxylic acid or a salt-thereof with an amine HNR 1 R 2 by suspending the ester in a C 1-3 alkanol containing the amine and heating the mixture for at least part of the time above 70‹ C. R 1 is hydrogen and R 2 is allyl, propargyl i-propyl, 2-hydroxyethyl or cyclopropyl.