Combinatorial hydroxy-amino acid amide libraries

Combinatorial hydroxy-amino acid amide libraries

Combination chemical libraries of Formula Iand methods for preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue of an N-acylated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROLLAND ELLWOOD DOLLE III, ZHEN MIN HE, THEODORE OTTO JOHNSON JR, TAO GUO, HITESH K. PATEL, SHIWEI TAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Combination chemical libraries of Formula Iand methods for preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or substituted piperazinealkanoic acid. The use of the libraries to discover biologically active compounds is also disclosed.