METHOD FOR PRODUCTION OF STABLE NICORANDIL PREPARATION WITH SUGAR AND OR POWDER ORGANIC ACID

A method for producing a stable pharmaceutical preparation containing nicorandil as an active ingredient is disclosed. The stable preparation is produced by mixing nicorandil, one or more finely comminuted sugars, and/or one or more powdery organic acids.Nicorandil which is useful as a curative for...

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Bibliographische Detailangaben
Hauptverfasser:	TAKASHI TERAZONO, SHUJI SUMIDA, YOSHIMITSU IIDA
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A method for producing a stable pharmaceutical preparation containing nicorandil as an active ingredient is disclosed. The stable preparation is produced by mixing nicorandil, one or more finely comminuted sugars, and/or one or more powdery organic acids.Nicorandil which is useful as a curative for various types of angina pectoris is not stable against the compressive pressure exerted by punching operations in tablet making or against moisture.The preparation of nicorandil manufactured by this invention is very stable and useful in clinical applications(Figure 1).