PROSTAGLANDIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS

A procedure for the preparation of new 3,5-dione-4,4-dimethyl pyrrolidine derivatives of formula (I): ** (Formula) ** where n is a number from 4 to 8; X is CO, CO protected or CROH where R is hydrogen or C1-4alkyl and where the OH radical can be protected; R1 is hydrogen, or CO2R1 represents an ester group in which the radical R1 contains from 1 to 12 carbon atoms; R3 is hydroxy or protected hydroxy; R2 and R4 are independently hydrogen, C1-9 alkyl, C5-8 cycloalkyl, (C5-8 cycloalkyl) (C1-6) alkyl, phenyl, phenyl-C1-6 alkyl, naphthyl, naphthyl-C1-6 alkyl), where any of the phenyl or naphthyl radicals can be substituted with one or more halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro groups; or R2 and R4 together with the carbon atom to which they are attached represent C5-8 cycloalkyl; A is hydrogen or methyl; or a salt thereof. (Machine-translation by Google Translate, not legally binding)