Plant-derived antigens against respiratory syncytial virus

A plant-derived vaccine against respiratory syncytial virus (RSV) is disclosed. The vaccine includes an immunogenic complex that includes plant cells transformed with a chimeric gene containing a nucleotide sequence adapted for protein expression in plants and an RSV coding sequence that encodes an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHUYLER S. KORBAN, DENNIS E. BUETOW, SERGEI F. KRASNYANSKI, JAGDEEP SANDHU
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A plant-derived vaccine against respiratory syncytial virus (RSV) is disclosed. The vaccine includes an immunogenic complex that includes plant cells transformed with a chimeric gene containing a nucleotide sequence adapted for protein expression in plants and an RSV coding sequence that encodes an antigenic protein of RSV. Also disclosed are methods of making the plant-derived vaccine of the invention, as well as transgenic plants, transgenic plant cells, and nucleic acid constructs useful in immunizing a mammal against RSV.